Literaturnachweis - Detailanzeige
Autor/inn/en | Aaron, Elizabeth; Montgomery, Alicia; Ren, Xinguo; Guter, Stephen; Anderson, George; Carneiro, Ana M. D.; Jacob, Suma; Mosconi, Matthew; Pandey, Ghanshyam N.; Cook, Edwin; Veenstra-VanderWeele, Jeremy |
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Titel | Whole Blood Serotonin Levels and Platelet 5-HT[subscript 2A] Binding in Autism Spectrum Disorder |
Quelle | In: Journal of Autism and Developmental Disorders, 49 (2019) 6, S.2417-2425 (9 Seiten)
PDF als Volltext |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 0162-3257 |
DOI | 10.1007/s10803-019-03989-z |
Schlagwörter | Autism; Pervasive Developmental Disorders; Physiology; Metabolism; Correlation |
Abstract | Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT[subscript 2A] binding has been reported in ASD. WB5-HT levels and platelet 5-HT[subscript 2A] specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT[subscript 2A] specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT[subscript 2A] binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD. (As Provided). |
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Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2020/1/01 |