Brief Report: Plasma Leptin Levels Are Elevated in Autism: Association with Early Onset Phenotype?

Autor/inn/en	Ashwood, Paul; Kwong, Christina; Hansen, Robin; Hertz-Picciotto, Irva; Croen, Lisa; Krakowiak, Paula; Walker, Wynn; Pessah, Isaac N.; Van de Water, Judy
Titel	Brief Report: Plasma Leptin Levels Are Elevated in Autism: Association with Early Onset Phenotype?
Quelle	In: Journal of Autism and Developmental Disorders, 38 (2008) 1, S.169-175 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-006-0353-1
Schlagwörter	Siblings; Autism; Developmental Disabilities; Correlation; Children; Metabolism; Comparative Analysis; Symptoms (Individual Disorders) + Suchen Sie Ihr Suchwort? Sibling; Geschwister; Autismus; Entwicklungsstörung; Korrelation; Child; Kind; Kinder; Stoffwechsel; Psychiatrische Symptomatik
Abstract	There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p less than 0.006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p less than 0.042), TD controls (p less than 0.0015), and DD controls (p less than 0.004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10