Structural Biology of Tumor Necrosis Factor Demonstrated for Undergraduates Instruction by Computer Simulation

Autor/in	Roy, Urmi
Titel	Structural Biology of Tumor Necrosis Factor Demonstrated for Undergraduates Instruction by Computer Simulation
Quelle	In: Biochemistry and Molecular Biology Education, 44 (2016) 3, S.246-255 (10 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1470-8175
DOI	10.1002/bmb.20937
Schlagwörter	Science Instruction; Cancer; Computer Simulation; Chemistry; Role; Genetics; Biochemistry; Cytology; Teaching Methods; Physiology; Undergraduate Students; Molecular Structure + Suchen Sie Ihr Suchwort? Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Carcinoma; Karzinom; Krebs (med); Krebserkrankung; Computergrafik; Computersimulation; Chemie; Rollen; Humangenetik; Biochemie; Zytologie; Teaching method; Lehrmethode; Unterrichtsmethode; Physiologie
Abstract	This work presents a three-dimensional (3D) modeling exercise for undergraduate students in chemistry and health sciences disciplines, focusing on a protein-group linked to immune system regulation. Specifically, the exercise involves molecular modeling and structural analysis of tumor necrosis factor (TNF) proteins, both wild type and mutant. The structure of the tumor necrosis factor type 1 receptor (TNF-R1) is also briefly explored. TNF and TNF-R1 play major roles in maintaining human immune-system homeostasis. Upon binding with TNFR-1, the TNF can activate the nuclear factor kappa B (NF-?B), eventually resulting in apoptosis or cell death. These essential features of the clinically relevant TNF family is explored within the frame work of a readily adaptable tutorial. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01