Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort

Autor/inn/en	Lampi, Katja M.; Hinkka-Yli-Salomäki, Susanna; Lehti, Venla; Helenius, Hans; Gissler, Mika; Brown, Alan S.; Sourander, Andre
Titel	Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort
Quelle	In: Journal of Autism and Developmental Disorders, 43 (2013) 11, S.2526-2535 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-013-1801-3
Schlagwörter	Foreign Countries; Cohort Analysis; Risk; Autism; Pervasive Developmental Disorders; Case Records; Regression (Statistics); Statistical Analysis; Experimental Groups; Control Groups; Age Differences; Gender Differences; Generational Differences; Parent Background; Epidemiology; Etiology; Finland + Suchen Sie Ihr Suchwort? Ausland; Kohortenanalyse; Risiko; Autismus; Case reports; Fallsammlung; Regression; Regressionsanalyse; Statistische Analyse; Age; Difference; Age difference; Altersunterschied; Geschlechterkonflikt; Elternhaus; Epidemiologie; Ätiologie; Finnland
Abstract	Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger's syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35-49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger's syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10