Correlation between Gray/White Matter Volume and Cognition in Healthy Elderly People

Autor/inn/en	Taki, Yasuyuki; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Wu, Kai; Kawashima, Ryuta; Fukuda, Hiroshi
Titel	Correlation between Gray/White Matter Volume and Cognition in Healthy Elderly People
Quelle	In: Brain and Cognition, 75 (2011) 2, S.170-176 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2010.11.008
Schlagwörter	Semantics; Cognitive Tests; Older Adults; Short Term Memory; Semiotics; Cognitive Processes; Brain; Evaluation Methods; Correlation; Health; Comparative Analysis; Visual Stimuli; Scientific Concepts; Science Education; Digit Span Test; Wechsler Adult Intelligence Scale + Suchen Sie Ihr Suchwort? Semantik; Kognitiver Fähigkeitstest; Älterer Erwachsener; Kurzzeitgedächtnis; Semiotik; Cognitive process; Kognitiver Prozess; Gehirn; Korrelation; Gesundheit; Naturwissenschaftliche Bildung
Abstract	This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109 community-dwelling healthy elderly individuals. We used the Information and Digit Span subtests of the Wechsler Adult Intelligent Scale-Revised as measures of semantic memory and short-term memory, respectively. We found significant positive correlations between the gray matter ratio, the percentage of gray matter volume in the intracranial volume, and performance on the Digit Span subtest, and between the regional gray matter volumes of the bilateral anterior temporal lobes and performance on the Information subtest. No significant correlations between performance on the cognitive tests and white matter volume were found. Our results suggest that individual variability in specific cognitive functions that are relatively well preserved with aging is accounted for by the variability of gray matter volume in healthy elderly subjects. (Contains 1 figure and 3 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10