Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood

Autor/inn/en	Newbury, Dianne F.; Gibson, Jenny L.; Conti-Ramsden, Gina; Pickles, Andrew; Durkin, Kevin; Toseeb, Umar
Titel	Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood
Quelle	In: Journal of Speech, Language, and Hearing Research, 62 (2019) 9, S.3381-3396 (16 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
Schlagwörter	Predictor Variables; Language Variation; Psychological Patterns; Social Development; Children; Genetics; Expressive Language; Child Language; Language Acquisition; Foreign Countries; Profiles; Scores; Peer Relationship; Behavior Problems; Language Impairments; Risk; United Kingdom + Suchen Sie Ihr Suchwort? Prädiktor; Sprachenvielfalt; Soziale Entwicklung; Child; Kind; Kinder; Humangenetik; 'Children''s language'; Kindersprache; Sprachaneignung; Spracherwerb; Ausland; Charakterisierung; Profilanalyse; Peer-Beziehungen; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Risiko; Großbritannien
Abstract	Purpose: Children with poor language tend to have worse psychosocial outcomes compared to their typically developing peers. The most common explanations for such adversities focus on developmental psychological processes whereby poor language triggers psychosocial difficulties. Here, we investigate the possibility of shared biological effects by considering whether the same genetic variants, which are thought to influence language development, are also predictors of elevated psychosocial difficulties during childhood. Method: Using data from the U.K.-based Avon Longitudinal Study of Parents and Children, we created a number of multi-single-nucleotide polymorphism polygenic profile scores, based on language and reading candidate genes ("ATP2C2," "CMIP," "CNTNAP2," "DCDC2," "FOXP2," and "KIAA0319," 1,229 single-nucleotide polymorphisms) in a sample of 5,435 children. Results: A polygenic profile score for expressive language (8 years) that was created in a discovery sample (n = 2,718) predicted not only expressive language (8 years) but also peer problems (11 years) in a replication sample (n = 2,717). Conclusions: These findings provide a proof of concept for the use of such a polygenic approach in child language research when larger data sets become available. Our indicative findings suggest consideration should be given to concurrent intervention targeting both linguistic and psychosocial development as early language interventions may not stave off later psychosocial difficulties in children. (As Provided).
Anmerkungen	American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01