Genome-Wide Polygenic Scores Predict Reading Performance throughout the School Years

Autor/inn/en	Selzam, Saskia; Dale, Philip S.; Wagner, Richard K.; DeFries, John C.; Cederlöf, Martin; O'Reilly, Paul F.; Krapohl, Eva; Plomin, Robert
Titel	Genome-Wide Polygenic Scores Predict Reading Performance throughout the School Years
Quelle	In: Scientific Studies of Reading, 21 (2017) 4, S.334-349 (16 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1088-8438
DOI	10.1080/10888438.2017.1299152
Schlagwörter	Genetics; Biological Sciences; Scores; Prediction; Reading Skills; Reading Tests; Foreign Countries; Reading Difficulties; Children; Adolescents; Reading Achievement; Reading Comprehension; Longitudinal Studies; Achievement Tests; Reading Ability; Intelligence Tests; Cognitive Ability; Socioeconomic Status; National Curriculum; United Kingdom (England); United Kingdom (Wales); Peabody Individual Achievement Test; Raven Progressive Matrices + Suchen Sie Ihr Suchwort? Humangenetik; Abwasserbiologie; Vorhersage; Reading skill; Lesefertigkeit; Lesetest; Ausland; Reading difficulty; Leseschwierigkeit; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Leseleistung; Leseverstehen; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Achievement test; Achievement; Testing; Test; Tests; Leistungsbeurteilung; Leistungsüberprüfung; Leistung; Testdurchführung; Testen; Reading competence; Lesekompetenz; Intelligence test; Intelligenztest; Denkfähigkeit; Socio-economic status; Sozioökonomischer Status
Abstract	It is now possible to create individual-specific genetic scores, called genome-wide polygenic scores (GPS). We used a GPS for years of education ("EduYears") to predict reading performance assessed at UK National Curriculum Key Stages 1 (age 7), 2 (age 12) and 3 (age 14) and on reading tests administered at ages 7 and 12 in a UK sample of 5,825 unrelated individuals. "EduYears" GPS accounts for up to 5% of the variance in reading performance at age 14. GPS predictions remained significant after accounting for general cognitive ability and family socioeconomic status. Reading performance of children in the lowest and highest 12.5% of the "EduYears" GPS distribution differed by a mean growth in reading ability of approximately two school years. It seems certain that polygenic scores will be used to predict strengths and weaknesses in education. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01