Maternal and Paternal Age Are Jointly Associated with Childhood Autism in Jamaica

Autor/inn/en	Rahbar, Mohammad H.; Samms-Vaughan, Maureen; Loveland, Katherine A.; Pearson, Deborah A.; Bressler, Jan; Chen, Zhongxue; Ardjomand-Hessabi, Manouchehr; Shakespeare-Pellington, Sydonnie; Grove, Megan L.; Beecher, Compton; Bloom, Kari; Boerwinkle, Eric
Titel	Maternal and Paternal Age Are Jointly Associated with Childhood Autism in Jamaica
Quelle	In: Journal of Autism and Developmental Disorders, 42 (2012) 9, S.1928-1938 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-011-1438-z
Schlagwörter	Autism; At Risk Persons; Age Differences; Foreign Countries; Mothers; Fathers; Parent Influence; Children; Educational Attainment; Effect Size; Comparative Analysis; Jamaica + Suchen Sie Ihr Suchwort? Autismus; Risikogruppe; Age; Difference; Age difference; Altersunterschied; Ausland; Mother; Mutter; Child; Kind; Kinder; Bildungsabschluss; Bildungsgut
Abstract	Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case-control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p less than 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10