Advancing Paternal Age and Simplex Autism

Autor/inn/en	Puleo, Connor Morrow; Schmeidler, James; Reichenberg, Abraham; Kolevzon, Alexander; Soorya, Latha V.; Buxbaum, Joseph D.; Silverman, Jeremy M.
Titel	Advancing Paternal Age and Simplex Autism
Quelle	In: Autism: The International Journal of Research and Practice, 16 (2012) 4, S.367-380 (14 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361311427154
Schlagwörter	Autism; Risk; Males; Age Differences; Parents; Gender Differences; Females; Predictor Variables; Symptoms (Individual Disorders); Mothers; Fathers; Interaction; Genetic Disorders; Incidence; Pervasive Developmental Disorders; Birth Order; Family Structure; Ethnicity; United States; Autism Diagnostic Observation Schedule + Suchen Sie Ihr Suchwort? Autismus; Risiko; Male; Männliches Geschlecht; Age; Difference; Age difference; Altersunterschied; Eltern; Geschlechterkonflikt; Weibliches Geschlecht; Prädiktor; Psychiatrische Symptomatik; Mother; Mutter; Interaktion; Vorkommen; Geburtenfolge; Familienkonstellation; Familiensystem; Ethnizität; USA
Abstract	De novo events appear more common in female and simplex autism spectrum disorder (ASD) cases and may underlie greater ASD risk in older fathers' offspring. This study examined whether advancing paternal age predicts an increase in simplex (n = 90) versus multiplex ASD cases (n = 587) in 677 participants (340 families). Whether or not controlling for maternal age, results support a significant interaction of linear paternal age and sex of the child on simplex family type. Female ASD cases were significantly more likely to be simplex as paternal age increased, but the increase for males was not significant. Findings suggest that ASD arising from non-familial, de novo events may be far less prominent in males than in females, even if more prevalent in males, due to the substantially larger number of male cases attributable to other, more strongly male-biased risk factors. (Contains 2 figures and 3 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10