Behavioral Correlates of Maternal Antibody Status among Children with Autism

Autor/inn/en	Braunschweig, Daniel; Duncanson, Paul; Boyce, Robert; Hansen, Robin; Ashwood, Paul; Pessah, Isaac N.; Hertz-Picciotto, Irva; Van de Water, Judy
Titel	Behavioral Correlates of Maternal Antibody Status among Children with Autism
Quelle	In: Journal of Autism and Developmental Disorders, 42 (2012) 7, S.1435-1445 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-011-1378-7
Schlagwörter	Mothers; Autism; Disability Identification; Children; Brain; Expressive Language; Pervasive Developmental Disorders; Comparative Analysis; Clinical Diagnosis; Check Lists; United States; Aberrant Behavior Checklist + Suchen Sie Ihr Suchwort? Mother; Mutter; Autismus; Child; Kind; Kinder; Gehirn; Checkliste; USA
Abstract	Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10