Association between Amygdala Response to Emotional Faces and Social Anxiety in Autism Spectrum Disorders

Autor/inn/en	Kleinhans, Natalia M.; Richards, Todd; Weaver, Kurt; Johnson, L. Clark; Greenson, Jessica; Dawson, Geraldine; Aylward, Elizabeth
Titel	Association between Amygdala Response to Emotional Faces and Social Anxiety in Autism Spectrum Disorders
Quelle	In: Neuropsychologia, 48 (2010) 12, S.3665-3670 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2010.07.022
Schlagwörter	Nonverbal Communication; Brain; Emotional Response; Autism; Anxiety; Pervasive Developmental Disorders; Correlation; Diagnostic Tests; Fear; Psychological Patterns; Comparative Analysis; Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Non-verbal communication; Nonverbale Kommunikation; Gehirn; Emotionales Verhalten; Autismus; Angst; Korrelation; Diagnostic test; Diagnostischer Test; Furcht
Abstract	Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities. To further explore the neural basis of abnormal emotional face processing in ASD, we conducted an fMRI study of emotional face matching in high-functioning adults with ASD and age, IQ, and gender matched controls. In addition, we investigated whether there was a relationship between self-reported social anxiety and fMRI activation. During fMRI scanning, study participants were instructed to match facial expressions depicting fear or anger. The control condition was a comparable shape-matching task. The control group evidenced significantly increased left prefrontal activation and decreased activation in the occipital lobes compared to the ASD group during emotional face matching. Further, within the ASD group, greater social anxiety was associated with increased activation in right amygdala and left middle temporal gyrus, and decreased activation in the fusiform face area. These results indicate that level of social anxiety mediates the neural response to emotional face perception in ASD. (Contains 3 tables and 2 figures.) (As Provided).
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Update	2017/4/10