Is the Inattentive Subtype of ADHD Different from the Combined/Hyperactive Subtype?

Autor/inn/en	Grizenko, Natalie; Paci, Michael; Joober, Ridha
Titel	Is the Inattentive Subtype of ADHD Different from the Combined/Hyperactive Subtype?
Quelle	In: Journal of Attention Disorders, 13 (2010) 6, S.649-657 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1087-0547
DOI	10.1177/1087054709347200
Schlagwörter	Body Weight; Mothers; Drinking; Pregnancy; Attention Deficit Hyperactivity Disorder; Attention Deficit Disorders; Comparative Analysis; Genetics; Outcomes of Treatment; Referral; Drug Therapy; Stress Variables; Behavior Problems + Suchen Sie Ihr Suchwort? Körpergewicht; Mother; Mutter; Trinken; Schwangerschaft; Attention deficit hyperactivity disorder; ADHS; Aufmerksamkeits-Defizit-Hyperaktivitäts-Störung; Aufmerksamkeitsstörung; Humangenetik
Abstract	Objective: To compare the ADHD combined/hyperactive subtype (ADHD/CH) to the ADHD inattentive subtype (ADHD/I) on the level of comorbidity, treatment response, and possible etiological factors. Method: A total of 371 clinically referred children diagnosed with ADHD aged between 6 and 12 years are recruited for a double-blind, placebo-controlled trial of methylphenidate. Comorbidity, treatment response, and stress during pregnancy are assessed for each participant. Genotyping is done for the DAT, DRD4, and 5-HTT genes. Mothers report smoking or alcohol consumption during their pregnancy and their child's birth weight. Results: The ADHD/CH children show both a higher frequency of conduct disorder and good response to treatment, are exposed to more moderate stress during their mothers' pregnancy, and show a higher frequency of L/L genotype for the 5-HTT-linked polymorphic region. Conclusion: The significant differences found between the ADHD/CH and the ADHD/I subtypes raise the possibility that the two may be separate disorders. (Contains 2 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10