Children's Attentional Biases and "5-HTTLPR" Genotype: Potential Mechanisms Linking Mother and Child Depression

Autor/inn/en	Gibb, Brandon E.; Benas, Jessica S.; Grassia, Marie; McGeary, John
Titel	Children's Attentional Biases and "5-HTTLPR" Genotype: Potential Mechanisms Linking Mother and Child Depression
Quelle	In: Journal of Clinical Child and Adolescent Psychology, 38 (2009) 3, S.415-426 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1537-4416
Schlagwörter	Mothers; At Risk Persons; Parent Influence; Genetics; Attention; Cognitive Processes; Depression (Psychology); Comparative Analysis; Symptoms (Individual Disorders); Visual Stimuli; Pictorial Stimuli; Beck Depression Inventory; Childrens Depression Inventory + Suchen Sie Ihr Suchwort? Mother; Mutter; Risikogruppe; Humangenetik; Aufmerksamkeit; Cognitive process; Kognitiver Prozess; Psychiatrische Symptomatik; Fantasieanregung
Abstract	In this study, we examined the roles of specific cognitive (attentional bias) and genetic ("5-HTTLPR") risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children's attentional biases, we found that children of mothers with a history of MDD during their children's lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the "5-HTTLPR" S or L[subscript G] allele than among those homozygous for the L[subscript A] allele. Next, conceptualizing mothers' levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child "5-HTTLPR" x attentional bias x mother depressive symptom interaction predicting children's depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the "5-HTTLPR" S or L[subscript G] allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children's "5-HTTLPR" genotype and attentional biases for sad faces in the intergenerational transmission of depression. (Contains 4 footnotes and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10