Autoimmune Diseases in Parents of Children with Infantile Autism: A Case--Control Study

Autor/inn/en	Mouridsen, Svend Erik; Rich, Bente; Isager, Torben; Nedergaard, Niels Jorgen
Titel	Autoimmune Diseases in Parents of Children with Infantile Autism: A Case--Control Study
Quelle	In: Developmental Medicine & Child Neurology, 49 (2007) 6, S.429-432 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1622
DOI	10.1111/j.1469-8749.2007.00429.x
Schlagwörter	Control Groups; Mothers; Autism; Diseases; Identification; Patients; Fathers; Comparative Analysis; Foreign Countries; Clinical Diagnosis; Pervasive Developmental Disorders; Correlation; Case Studies; Denmark + Suchen Sie Ihr Suchwort? Mother; Mutter; Autismus; Disease; Krankheit; Identifikation; Identifizierung; Patient; Ausland; Korrelation; Case study; Fallstudie; Case Study; Dänemark
Abstract	This register study compared the rates and types of autoimmune disease in the parents of 111 patients (82 males, 29 females; mean age at diagnosis 5y 5mo [SD 2y 6mo]) with infantile autism (IA) with a matched control group of parents of 330 children from the general population. All parents were screened through the nationwide Danish National Hospital Register. We inquired about 35 autoimmune diseases during an observation period of 27 years. At follow-up the case and control mothers were identical in age (65y 7mo [SDs 9y 7mo and 9y respectively]). For case and control fathers the figures were 70 years 2 months (SD 10y 2mo) and 69 years 1 month (SD 10y 1mo) respectively. A similar proportion of case and control mothers had a diagnosis of any autoimmune disease: 10.8% versus 9.1%. For case fathers the proportion was 8.6% versus 4.6%. Two autoimmune conditions were associated with IA: ulcerative colitis in mothers (p=0.05) and type 1 diabetes in fathers (p=0.02). Additional studies are required to determine whether there is a true association between a parental history of autoimmune disease and pervasive developmental disorder in their offspring. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10