An Idea to Explore: Engaging High School Students in Structure-Function Studies of Bacterial Sortase Enzymes and Inhibitors -- A Comprehensive Computational Experimental Pipeline

Autor/inn/en	Godse, Shivani; Sapar, Tanvi; Amacher, Jeanine F.
Titel	An Idea to Explore: Engaging High School Students in Structure-Function Studies of Bacterial Sortase Enzymes and Inhibitors -- A Comprehensive Computational Experimental Pipeline
Quelle	In: Biochemistry and Molecular Biology Education, 51 (2023) 6, S.606-615 (10 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Amacher, Jeanine F.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1470-8175
DOI	10.1002/bmb.21769
Schlagwörter	High School Students; Biology; Science Fairs; Science Projects; College School Cooperation; Learner Engagement + Suchen Sie Ihr Suchwort? High school; High schools; Student; Students; Oberschule; Schüler; Schülerin; Studentin; Biologie; Science; Project; Wissenschaft; Projekt
Abstract	High school science fairs provide an exceptional opportunity for students to gain experience with scientific research, and participation has positive outcomes with respect to chosen careers in the sciences. However, it can be challenging to engage high school students in university-level research outside of formal internship programs. Here, we describe an experimental pipeline for a computational structural biology project that engages high school students. Students are involved at every step of the investigation and utilize freely available software to dock inhibitors onto protein homologues, and then analyze the resulting complexes. Bacterial sortases are transpeptidases on the cell surface of Gram-positive bacteria and are a potential target for the development of antibiotics. Students modeled inhibitors bound to sortases from several organisms, asking questions about affinity and selectivity. Their project was ranked in the top 10% at both regional and state science fairs. This project design is easily adaptable to countless other protein systems and provides a pipeline for collaborative high school student/university professor inquiry. (As Provided).
Anmerkungen	Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01