Literaturnachweis - Detailanzeige
| Autor/inn/en | Han, Yvonne M.Y.; Chan, Melody M.Y.; Shea, Caroline K.S.; Mo, Flora Y.M.; Yiu, Klaire W.K.; Chung, Raymond C.K.; Cheung, Mei-Chun; Chan, Agnes S. |
|---|---|
| Titel | Effects of Prefrontal Transcranial Direct Current Stimulation on Social Functioning in Autism Spectrum Disorder: A Randomized Clinical Trial |
| Quelle | In: Autism: The International Journal of Research and Practice, 27 (2023) 8, S.2465-2482 (18 Seiten)
PDF als Volltext |
| Zusatzinformation | ORCID (Chan, Melody M.Y.) ORCID (Chan, Agnes S.) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 1362-3613 |
| DOI | 10.1177/13623613231169547 |
| Schlagwörter | Autism Spectrum Disorders; Brain Hemisphere Functions; Stimulation; Stimuli; Adolescents; Young Adults; Program Effectiveness; Interpersonal Competence; Training; Behavior Modification; Interpersonal Communication; Behavior Problems; Cognitive Restructuring; Foreign Countries; Hong Kong |
| Abstract | This triple-arm, double-blind, randomized clinical trial investigated the effect of multisession prefrontal transcranial direct current stimulation (tDCS) on social functioning in individuals with autism spectrum disorder (ASD). A total of 105 individuals (age 14-21 years) diagnosed with ASD were randomized into the active-tDCS, sham-tDCS, and waitlist control groups. The experimental group received 20 min of 1.5 mA tDCS stimulation (cathode: F3; anode: Fp2) for 10 days with concurrent computerized cognitive remediation training. Changes in overall social functioning, social communication, and restricted, repetitive behaviors (RRB) were measured by the Social Responsiveness Scale-2nd edition (SRS-2). Two-level hierarchical linear mixed-model analysis showed significant group*time interactions for SRS-2 total [F(2, 107.09) = 7.82; p = 0.001] and RRB [F(2, 90.26) = 5.62; p = 0.005] T-scores. When compared with the waitlist control group, the changes in scores were only significant in active-tDCS (SRS-2 total T-score p < 0.001, d = 0.61; SRS-2 RRB T-score p = 0.002, d = 0.88), but not sham-tDCS (SRS-2 total T-score p < 0.12, d = 0.30; SRS-2 RRB T-score p = 0.54, d = 0.17) group. Multiple sessions of prefrontal tDCS coupled with cognitive training is a safe and effective treatment for improving social functioning in people with ASD. Trial Registration: ClinicalTrials.gov (ID: NCT03814083; URL: https://clinicaltrials.gov/ct2/show/NCT03814083). (As Provided). |
| Anmerkungen | SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2024/1/01 |
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