Literaturnachweis - Detailanzeige
| Autor/inn/en | Carey, Meghan E.; Rando, Juliette; Melnyk, Stepan; James, S. Jill; Snyder, Nathaniel; Salafia, Carolyn; Croen, Lisa A.; Fallin, M. Daniele; Hertz-Picciotto, Irva; Volk, Heather; Newschaffer, Craig; Lyall, Kristen |
|---|---|
| Titel | Examining Associations between Prenatal Biomarkers of Oxidative Stress and ASD-Related Outcomes Using Quantile Regression |
| Quelle | In: Journal of Autism and Developmental Disorders, 53 (2023) 8, S.2975-2985 (11 Seiten)
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| Zusatzinformation | ORCID (Carey, Meghan E.) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0162-3257 |
| DOI | 10.1007/s10803-022-05625-9 |
| Schlagwörter | Physiology; Prenatal Influences; Autism Spectrum Disorders; Pregnancy; Siblings; Biochemistry; Interpersonal Competence; Correlation; Children; Social Responsiveness Scale |
| Abstract | We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile [beta]: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. (As Provided). |
| Anmerkungen | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2024/1/01 |
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