"FMR1" CGG Repeats and Stress Influence Self-Reported Cognitive Functioning in Mothers

Autor/inn/en	Maltman, Nell; DaWalt, Leeann Smith; Hong, Jinkuk; Baker, Mei Wang; Berry-Kravis, Elizabeth M.; Brilliant, Murray H.; Mailick, Marsha
Titel	"FMR1" CGG Repeats and Stress Influence Self-Reported Cognitive Functioning in Mothers
Quelle	In: American Journal on Intellectual and Developmental Disabilities, 128 (2023) 1, S.1-20 (20 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1944-7515
Schlagwörter	Genetics; Cognitive Ability; Executive Function; Memory; Stress Variables; Mothers; Children; Developmental Disabilities; Predictor Variables; Environmental Influences + Suchen Sie Ihr Suchwort? Humangenetik; Denkfähigkeit; Gedächtnis; Mother; Mutter; Child; Kind; Kinder; Entwicklungsstörung; Prädiktor; Environmental influence; Umwelteinfluss
Abstract	Variation in the "FMR1" gene may affect aspects of cognition, such as executive function and memory. Environmental factors, such as stress, may also negatively impact cognitive functioning. Participants included 1,053 mothers of children with and without developmental disabilities. Participants completed self-report measures of executive function, memory, and stress (i.e., life events, parenting status), and provided DNA to determine CGG repeat length (ranging from 7 to 192 CGGs). Stress exposure significantly predicted greater self-reported difficulties in executive function and the likelihood of memory problems. Cubic CGG effects independently predicted executive function and memory difficulties, suggesting effects of both genetic variation and environmental stress exposure on cognitive functioning. (As Provided).
Anmerkungen	American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: https://meridian.allenpress.com/aaidd
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01