Maternal Obesity, Diabetes, Preeclampsia, and Asthma during Pregnancy and Likelihood of Autism Spectrum Disorder with Gastrointestinal Disturbances in Offspring

Autor/inn/en	Carter, Sarah A.; Lin, Jane C.; Chow, Ting; Yu, Xin; Rahman, Md Mostafijur; Martinez, Mayra P.; Feldman, Klara; Eckel, Sandrah P.; Chen, Jiu-Chiuan; Chen, Zhanghua; Levitt, Pat; Lurmann, Frederick W.; McConnell, Rob; Xiang, Anny H.
Titel	Maternal Obesity, Diabetes, Preeclampsia, and Asthma during Pregnancy and Likelihood of Autism Spectrum Disorder with Gastrointestinal Disturbances in Offspring
Quelle	In: Autism: The International Journal of Research and Practice, 27 (2023) 4, S.916-926 (11 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Carter, Sarah A.) ORCID (Xiang, Anny H.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/13623613221118430
Schlagwörter	Mothers; Pregnancy; Obesity; Diabetes; Hypertension; Diseases; Probability; Autism Spectrum Disorders; Children; California + Suchen Sie Ihr Suchwort? Mother; Mutter; Schwangerschaft; Adipositas; Bluthochdruck; Hypertonie; Disease; Krankheit; Wahrscheinlichkeitsrechnung; Wahrscheinlichkeitstheorie; Autism; Autismus; Child; Kind; Kinder; Kalifornien
Abstract	Gastrointestinal disturbances (GIDs) are relatively common in children diagnosed with autism spectrum disorder (ASD). This study assessed associations between maternal obesity, diabetes, preeclampsia, and asthma and likelihood of ASD with GIDs. This retrospective cohort study included 308,536 mother-child pairs of singletons born between 2001 and 2014 in a single integrated health care system. Social demographics, maternal health conditions during pregnancy, and child's ASD and/or GID diagnosis by age 5 were extracted from electronic medical records. Child's outcome was classified as: no ASD no GIDs; no ASD with GIDs; ASD no GIDs; and ASD with GIDs. Multinomial logistic regression was used to estimate odds ratios of child's outcomes associated with maternal exposures, adjusting for covariates. Compared to children with neither disorder, each maternal condition was associated with higher odds of no ASD with GIDs, ASD no GIDs, and ASD with GIDs. Association was greatest for likelihood of ASD with GIDs (Maternal obesity odds ratio (95% confidence interval): 1.37 (1.22-1.54); Diabetes: 1.50 (1.28-1.76); Preeclampsia: 1.63 (1.36-1.95); Asthma: 1.39 (1.17-1.67); relative to no ASD no GIDs). Associations were robust to mutual adjustment for all maternal exposures. Maternal obesity, diabetes, preeclampsia, and asthma exposure during pregnancy may increase likelihood of both GIDs and ASD with or without co-occurring GIDs in offspring. This association was greatest in children diagnosed with ASD with co-occurring GIDs. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01