Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort

Autor/inn/en	Palm, Camilla V. B.; Glintborg, Dorte; Find, Laura G.; Larsen, Pia V.; Dalgaard, Cilia M.; Boye, Henriette; Jensen, Tina K.; Dreyer, Anja F.; Andersen, Marianne S.; Bilenberg, Niels
Titel	Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort
Quelle	In: Journal of Autism and Developmental Disorders, 53 (2023) 3, S.1053-1065 (13 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Glintborg, Dorte)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-022-05446-w
Schlagwörter	Prenatal Influences; Autism Spectrum Disorders; Correlation; Mothers; Children; Biochemistry; Pregnancy; Males; Symptoms (Individual Disorders); Preschool Children; Metabolism; Physiology; Child Behavior Checklist + Suchen Sie Ihr Suchwort? Pränataler Einfluss; Autism; Autismus; Korrelation; Mother; Mutter; Child; Kind; Kinder; Biochemie; Schwangerschaft; Male; Männliches Geschlecht; Psychiatrische Symptomatik; Pre-school age; Preschool age; Children; Pre-school education; Preschool education; Vorschulalter; Vorschulkind; Vorschulkinder; Vorschulerziehung; Vorschule; Stoffwechsel; Physiologie
Abstract	Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother-child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 1 1/2-5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure. (As Provided).
Anmerkungen	Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01