Acoustic and Kinematic Assessment of Motor Speech Impairment in Patients with Suspected Four-Repeat Tauopathies

Autor/inn/en	Cordella, Claire; Gutz, Sarah E.; Eshghi, Marziye; Stipancic, Kaila L.; Schliep, Megan; Dickerson, Bradford C.; Green, Jordan R.
Institution	National Institutes of Health (NIH) (DHHS)
Titel	Acoustic and Kinematic Assessment of Motor Speech Impairment in Patients with Suspected Four-Repeat Tauopathies
Quelle	In: Journal of Speech, Language, and Hearing Research, 65 (2022) 11, S.4112-4132 (21 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Cordella, Claire) ORCID (Gutz, Sarah E.) ORCID (Eshghi, Marziye) ORCID (Stipancic, Kaila L.) ORCID (Schliep, Megan) ORCID (Green, Jordan R.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
Schlagwörter	Acoustics; Speech Impairments; Psychomotor Skills; Patients; Neurological Impairments; Severity (of Disability); Auditory Perception; Massachusetts + Suchen Sie Ihr Suchwort? Akustik; Speech impairment; Speech handicap; Speech handicaps; Language handicps; Language impairments; Sprachbehinderung; Psychomotorische Aktivität; Patient; Neurodegenerative Erkrankung; Schweregrad; Auditive Wahrnehmung; Akustische Wahrnehmung; Master-Studiengang
Abstract	Purpose: The aim of this study was to use acoustic and kinematic speech measures to characterize type of motor speech impairment--apraxia of speech (AOS) versus dysarthria--in individuals with four-repeat tauopathy (4RT)-associated syndromes, including nonfluent variant primary progressive aphasia (nfvPPA), primary progressive AOS (PPAOS), corticobasal syndrome (CBS), and progressive supranuclear palsy syndrome (PSPs). Method: Twenty patient participants were recruited and stratified into two groups: (a) a motor-speech-impaired group of individuals with nfvPPA, PPAOS, CBS, or PSPs and suspected 4RT pathology ("MSI+") and (b) a non-- motor-speech-impaired group of individuals with logopenic variant primary progressive aphasia ("MSI-"). Ten healthy, age-matched controls also participated in the study. Participants completed a battery of speech tasks, and 15 acoustic and kinematic speech measures were derived. Quantitative speech measures were grouped into feature categories ("AOS features," "dysarthria features," "shared features"). In addition to quantitative speech measures, two certified speech-language pathologists made independent, blinded auditoryperceptual ratings of motor speech impairment. A principal component analysis (PCA) was conducted to investigate the relative contributions of quantitative features. Results: Quantitative speech measures were generally concordant with independent clinician ratings of motor speech impairment severity. Hypothesis-driven groupings of quantitative measures differentiated predominantly apraxic from predominantly dysarthric presentations within the MSI+ group. PCA results provided additional evidence for differential profiles of motor speech impairment in the MSI+ group; heterogeneity across individuals is explained in large part by varying levels of overall severity--captured by the shared feature variable group--and degree of apraxia severity, as measured by the AOS feature variable group. Conclusions: Quantitative features reveal heterogeneity of MSI in the 4RT group in terms of both overall severity and subtype of MSI. Results suggest the potential for acoustic and kinematic speech assessment methods to inform characterization of motor speech impairment in 4RT-associated syndromes. (As Provided).
Anmerkungen	American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01