Oxytocin Exposure in Labor and Its Relationship with Cognitive Impairment and the Genetic Architecture of Autism

Autor/inn/en	García-Alcón, Alicia; González-Peñas, Javier; Weckx, Elisa; Penzol, M. J.; Gurriarán, Xaquín; Costas, Javier; Díaz-Caneja, Covadonga M.; Moreno, Carmen; Hernández, Patricia; Arango, Celso; Parellada, Mara
Titel	Oxytocin Exposure in Labor and Its Relationship with Cognitive Impairment and the Genetic Architecture of Autism
Quelle	In: Journal of Autism and Developmental Disorders, 53 (2023) 1, S.66-79 (14 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (García-Alcón, Alicia)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-05409-7
Schlagwörter	Genetics; Autism Spectrum Disorders; Prenatal Influences; Prenatal Care; Birth; Risk; Symptoms (Individual Disorders); Cognitive Development + Suchen Sie Ihr Suchwort? Humangenetik; Autism; Autismus; Pränataler Einfluss; Pränatale Versorgung; Geburt; Risiko; Psychiatrische Symptomatik; Kognitive Entwicklung
Abstract	Whether there is a relationship between oxytocin (OXT) use in labor and the risk of autism (ASD), and the nature of such relationship, is unclear. By integrating genetic and clinical data in a sample of 176 ASD participants, we tested the hypothesis that OXT is a marker for abnormal prenatal development which leads to impairments in the process of labor. OXT-exposed ASD had more obstetric complications (P = 0.031), earlier onset of symptoms (P = 0.027), poorer cognitive development (P = 0.011), higher mutation burden across neurodevelopment genes (P = 0.020; OR = 5.33) and lower transmission of polygenic risk for ASD (P = 0.0319), than non-exposed ASD. OXT seems to constitute a risk indicator rather than a risk factor for ASD, which is relevant for diagnostic and genetic counselling. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01