Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder

Autor/inn/en	Wang, Lei; Zheng, Ruixuan; Xu, Ying; Zhou, Ziyun; Guan, Ping; Wu, Yanling; Zhou, Jian; Cheng, Zaohuo; Zhang, Lili
Titel	Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 11, S.4897-4907 (11 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Zhang, Lili)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-05364-3
Schlagwörter	Males; Autism Spectrum Disorders; Control Groups; Biochemistry; Metabolism; Child Development; Behavior; Screening Tests; Young Children + Suchen Sie Ihr Suchwort? Male; Männliches Geschlecht; Autism; Autismus; Biochemie; Stoffwechsel; Kindesentwicklung; Screening-Verfahren; Frühe Kindheit
Abstract	Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 ± 0.67 years) and 30 typically developing (TD) boys (3.13 ± 0.46 years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography--tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01