Early Life Environmental Factors Associated with Autism Spectrum Disorder Symptoms in Children at Age 2 Years: A Birth Cohort Study

Autor/inn/en	Pham, Cindy; Symeonides, Christos; O'Hely, Martin; Sly, Peter D.; Knibbs, Luke D.; Thomson, Sarah; Vuillermin, Peter; Saffery, Richard; Ponsonby, Anne-Louise
Titel	Early Life Environmental Factors Associated with Autism Spectrum Disorder Symptoms in Children at Age 2 Years: A Birth Cohort Study
Quelle	In: Autism: The International Journal of Research and Practice, 26 (2022) 7, S.1864-1881 (18 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Pham, Cindy)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/13623613211068223
Schlagwörter	Autism Spectrum Disorders; Symptoms (Individual Disorders); Preschool Children; Toddlers; Socioeconomic Status; Family Structure; Gender Differences; Age Differences; Low Income Groups; Parents; Mothers; Health; Prenatal Influences; Drinking; Pollution; Environmental Influences; Smoking; Family Environment; Fuels; Birth Order; Depression (Psychology); Parent Influence; Foreign Countries; Check Lists; Child Behavior; Perinatal Influences; Australia; Child Behavior Checklist + Suchen Sie Ihr Suchwort? Autism; Autismus; Psychiatrische Symptomatik; Pre-school age; Preschool age; Child; Children; Pre-school education; Preschool education; Vorschulalter; Kind; Kinder; Vorschulkind; Vorschulkinder; Vorschulerziehung; Vorschule; Infant; Infants; Toddler; Kleinkind; Socio-economic status; Sozioökonomischer Status; Familienkonstellation; Familiensystem; Geschlechterkonflikt; Age; Difference; Age difference; Altersunterschied; Eltern; Mother; Mutter; Gesundheit; Pränataler Einfluss; Trinken; Schadstoffbelastung; Environmental influence; Umwelteinfluss; Rauchen; Familienmilieu; Treibstoff; Geburtenfolge; Ausland; Checkliste; Perinatalperiode; Australien
Abstract	Mounting evidence finds that early life environmental factors increased the probability of autism spectrum disorder. We estimated prospective associations between early life environmental factors and autism spectrum disorder symptoms in children at the age of 2 years in a population-derived birth cohort, the Barwon Infant Study. Autism spectrum disorder symptoms at the age of 2 years strongly predicted autism spectrum disorder diagnosis by the age of 4 years (area under curve = 0.93; 95% CI (0.82, 1.00)). After adjusting for child's sex and age at the time of behavioural assessment, markers of socioeconomic disadvantage, such as lower household income and lone parental status; maternal health factors, including younger maternal age, maternal pre-pregnancy body mass index, higher gestational weight gain and prenatal maternal stress; prenatal alcohol; environmental air pollutant exposures, including particulate matter < 2.5 [mu]m at birth, child secondhand tobacco smoke exposure at 12 months, dampness/mould and home heating with oil, kerosene or diesel heaters at 2 years postnatal. Lower socioeconomic indexes for area, later birth order, higher maternal prenatal depression, and maternal smoking frequency had a dose-response relationship with autism spectrum disorder symptoms. Future studies on environmental factors and autism spectrum disorder should consider the reasons for the socioeconomic disparity and the combined impact of multiple environmental factors through common mechanistic pathways. [Written with the Barwon Infant Study Investigator Group.] (As Provided).
Anmerkungen	SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01