Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-Analysis and Meta-Regression

Autor/inn/en	Liu, Xian; Zou, Mingyang; Sun, Caihong; Wu, Lijie; Chen, Wen-Xiong
Titel	Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-Analysis and Meta-Regression
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 2, S.522-539 (18 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Liu, Xian) ORCID (Chen, Wen-Xiong)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-04951-8
Schlagwörter	Autism; Pervasive Developmental Disorders; Children; Mothers; Nutrition; Pregnancy; Prenatal Influences; Risk Management + Suchen Sie Ihr Suchwort? Autismus; Child; Kind; Kinder; Mother; Mutter; Ernährung; Schwangerschaft; Pränataler Einfluss; Risikomanagement
Abstract	We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 [mu]g folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01