Exploration of a Simplified Protocol for Solid Lipid Nanoparticle Production and Characterization

Autor/inn/en	Loureiro, Joana A.; Pereira, Maria C.
Titel	Exploration of a Simplified Protocol for Solid Lipid Nanoparticle Production and Characterization
Quelle	In: Journal of Chemical Education, 98 (2021) 8, S.2693-2698 (6 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Loureiro, Joana A.) ORCID (Pereira, Maria C.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.1c00426
Schlagwörter	Laboratory Experiments; Science Instruction; Graduate Students; Masters Programs; Technology; College Science; Hands on Science; Chemistry; Chemical Engineering + Suchen Sie Ihr Suchwort? Laboratory work; Laborarbeit; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Graduate Study; Student; Students; Aufbaustudium; Graduiertenstudium; Hauptstudium; Studentin; Magister course; Magisterstudiengang; Technologie; Chemie; Chemisches Prüfverfahren
Abstract	Solid lipid nanoparticles (SLNs) are exciting nanoparticles used for transporting therapeutic drugs into an organism. In this laboratory work, a simple experiment is performed to introduce master's students into the field of nanotechnology, here applied to health including the applications in the healthcare/pharmaceutical and cosmetic industry. This work demonstrates the advantages of SLNs as a vehicle to deliver/transport hydrophobic molecules. The experiments are designed to be accomplished in two parts, i.e., two practical classes of 120 min each. In the first part, students will produce SLNs using homogenization followed by the ultrasonication method. In the second part, the SLNs will be characterized through their hydrodynamic size, polydispersity index, and zeta potential and microscopically observed using a fluorescence microscope. Their encapsulation efficiency (EE) and loading capacity (LC) will be calculated. This laboratory work could be performed in groups of two students. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01