Oral Bisphosphonates for Osteoporosis in Adult Males with Intellectual Disabilities

Autor/inn/en	May, Philip B.; Parker, Frank
Titel	Oral Bisphosphonates for Osteoporosis in Adult Males with Intellectual Disabilities
Quelle	In: Journal of Applied Research in Intellectual Disabilities, 34 (2021) 3, S.921-925 (5 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (May, Philip B.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1360-2322
DOI	10.1111/jar.12862
Schlagwörter	Intellectual Disability; Males; Drug Therapy; At Risk Persons; Physiology; Human Body; Program Effectiveness; Adults + Suchen Sie Ihr Suchwort? Intellect; Disability; Disabilities; Verstand; Behinderung; Male; Männliches Geschlecht; Risikogruppe; Physiologie; Menschlicher Körper
Abstract	Introduction: Oral bisphosphonates are first-line agents for treating osteoporosis in men, but there are no studies regarding efficacy of oral bisphosphonates for treatment of osteoporosis in ambulatory male adults with intellectual disability. Methods: Nine adult males with intellectual disability and increased fracture risk had been treated with weekly or monthly oral bisphosphonates, vitamin D and calcium for 1-3 years. Post-treatment bone mineral density (BMD), serum 25(OH)D, parathyroid hormone and C-telopeptide of type I collagen were then determined for the first time. Results: Weekly or monthly oral bisphosphonates were well tolerated and led to significant increases in BMD in all 9 individuals. Serum 25(OH)D level enhanced the "percent increase of BMD" that occurred in response to bisphosphonate treatment (p < 0.05). Conclusions: Weekly or monthly oral bisphosphonates are well tolerated by ambulatory adult males with ID and are effective in increasing BMD. Higher serum levels of vitamin D appear to improve the efficacy of bisphosphonates and therefore reduce fracture risk in adult males with intellectual disability. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01