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Autor/inn/en | Olson, Lindsay A.; Mash, Lisa E.; Linke, Annika; Fong, Christopher H.; Müller, Ralph-Axel; Fishman, Inna |
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Titel | Sex-Related Patterns of Intrinsic Functional Connectivity in Children and Adolescents with Autism Spectrum Disorders |
Quelle | In: Autism: The International Journal of Research and Practice, 24 (2020) 8, S.2190-2201 (12 Seiten)
PDF als Volltext |
Zusatzinformation | ORCID (Olson, Lindsay A.) ORCID (Mash, Lisa E.) ORCID (Fishman, Inna) |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 1362-3613 |
DOI | 10.1177/1362361320938194 |
Schlagwörter | Autism; Pervasive Developmental Disorders; Gender Differences; Children; Adolescents; Correlation; Symptoms (Individual Disorders); Brain; Brain Hemisphere Functions; Cognitive Processes; New York; District of Columbia; Maryland; Oregon; Autism Diagnostic Observation Schedule; Wechsler Abbreviated Scale of Intelligence; Wechsler Intelligence Scale for Children |
Abstract | Although a growing literature highlights sex differences in autism spectrum disorder clinical presentation, less is known about female variants at the neural level. We investigated sex-related patterns of functional connectivity within and between functional networks in children and adolescents with autism spectrum disorders, compared to typically developing peers. Resting-state functional magnetic resonance imaging data for 141 children and adolescents (7-17 years) selected from an in-house sample and four sites contributing to the Autism Brain Imaging Database Exchange (ABIDE I and II) were submitted to group independent component analysis to generate resting-state functional networks. Functional connectivity was estimated by generating resting-state functional network correlation matrices, which were directly compared between males and females, and autism spectrum disorder and typically developing groups. Results revealed greater connectivity within the default mode network in typically developing girls as compared to typically developing boys, while no such sex effect was observed in the autism spectrum disorder group. Correlational analyses with clinical indices revealed a negative relationship between sensorimotor connectivity and history of early autism symptoms in girls, but not in boys with autism spectrum disorder. A lack of neurotypical sex differentiation in default mode network functional connectivity observed in boys and girls with autism spectrum disorder suggests that sex-related differences in network integration may be altered in autism spectrum disorder. (As Provided). |
Anmerkungen | SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: http://sagepub.com |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2024/1/01 |