Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference

Autor/inn/en	Panjwani, Anita A.; Ji, Yuelong; Fahey, Jed W.; Palmer, Amanda; Wang, Guoying; Hong, Xiumei; Zuckerman, Barry; Wang, Xiaobin
Titel	Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference
Quelle	In: Journal of Autism and Developmental Disorders, 50 (2020) 2, S.540-550 (11 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Wang, Xiaobin)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-019-04264-x
Schlagwörter	Obesity; Diabetes; Autism; Pervasive Developmental Disorders; Mothers; Biochemistry; Risk; Children; Gender Differences; Cohort Analysis; Urban Population; Low Income Groups + Suchen Sie Ihr Suchwort? Adipositas; Autismus; Mother; Mutter; Biochemie; Risiko; Child; Kind; Kinder; Geschlechterkonflikt; Kohortenanalyse; Stadtbevölkerung
Abstract	In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), the roles of maternal dyslipidemia and sex disparity in ASD have not been well-studied. We examined the joint associations of maternal plasma cholesterols, branched-chain amino acids (BCAAs) and child sex on child ASD risk. We analyzed data from 756 mother-infant pairs (86 ASD) from the Boston Birth Cohort. Maternal plasma cholesterols and BCAAs were measured in samples collected 24-72 h postpartum. We found that in this urban, low-income prospective birth cohort, low maternal high-density lipoprotein cholesterol (HDL-C), above-median maternal plasma BCAA concentrations, and male sex additively or synergistically increased risk of ASD. Additional studies are necessary to confirm our findings. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01