Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review

Autor/inn/en	Lukasik, Jan; Patro-Golab, Bernadeta; Horvath, Andrea; Baron, Ruth; Szajewska, Hania
Titel	Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review
Quelle	In: Journal of Autism and Developmental Disorders, 49 (2019) 9, S.3866-3876 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-019-04093-y
Schlagwörter	Autism; Pervasive Developmental Disorders; Correlation; At Risk Persons; Literature Reviews; Prenatal Influences; Drug Use + Suchen Sie Ihr Suchwort? Autismus; Korrelation; Risikogruppe; Pränataler Einfluss; Drug consumption; Substance abuse; Drogenkonsum
Abstract	We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case-control study; in three other case-control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case-control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis that early-life antibiotic exposure is associated with subsequent ASD development. [Co-written with the Sarphati Amsterdam/Warsaw group on ANtibiotic long-Term Impacts (SAWANTI) Working Group.] (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01