"NR3C1" Methylation as a Moderator of the Effects of Maternal Support and Stress on Insecure Attachment Development

Autor/inn/en	Bosmans, Guy; Young, Jami F.; Hankin, Benjamin L.
Titel	"NR3C1" Methylation as a Moderator of the Effects of Maternal Support and Stress on Insecure Attachment Development
Quelle	In: Developmental Psychology, 54 (2018) 1, S.29-38 (10 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Bosmans, Guy)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1649
DOI	10.1037/dev0000422
Schlagwörter	Interaction; Genetics; Stress Variables; Mothers; Predictor Variables; Anxiety; Attachment Behavior; Child Development; Parent Child Relationship; Children; Adolescents; Longitudinal Studies; Physiology; Interviews; Questionnaires; Hypothesis Testing; Emotional Development; Social Development; Check Lists; Child Behavior; Depression (Psychology); Statistical Analysis; Correlation; Colorado; New Jersey; Child Behavior Checklist + Suchen Sie Ihr Suchwort? Interaktion; Humangenetik; Mother; Mutter; Prädiktor; Angst; Attachment; Bindungsverhalten; Kindesentwicklung; Parents-child relationship; Parent-child-relation; Parent-child relationship; Eltern-Kind-Beziehung; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Physiologie; Interviewing; Interviewtechnik; Fragebogen; Hypothesenprüfung; Hypothesentest; Gefühlsbildung; Soziale Entwicklung; Checkliste; Statistische Analyse; Korrelation
Abstract	We examined the prediction that the interaction between Glucocorticoid Receptor Gene ("NR3C1") methylation, stress, and experienced maternal support predicts anxious and avoidant attachment development. This was tested in a general population sample of 487 children and adolescents (44% boys, M[subscript age] = 11.84, SD[subscript age] = 2.4). These children were followed over a period of 18 months. In line with the prediction, we found that "NR3C1" methylation moderates the effect of maternal support during stress on anxious attachment development 18 months later. More stressed children who experienced less maternal support reported increased anxious attachment when their "NR3C1" gene was highly methylated. This effect could not be explained by children's level of psychopathology. No effects were found for attachment avoidance. These data provide the first prospective evidence that epigenetic processes are involved in attachment development. (As Provided).
Anmerkungen	American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01