Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay

Autor/inn/en	Lyall, Kristen; Ashwood, Paul; Van de Water, Judy; Hertz-Picciotto, Irva
Titel	Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
Quelle	In: Journal of Autism and Developmental Disorders, 44 (2014) 7, S.1546-1555 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-013-2017-2
Schlagwörter	Autism; Pervasive Developmental Disorders; Developmental Delays; Diseases; Regression (Statistics); Mothers; Risk + Suchen Sie Ihr Suchwort? Autismus; Entwicklungsverzögerung; Disease; Krankheit; Regression; Regressionsanalyse; Mother; Mutter; Risiko
Abstract	The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95% CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD). (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10