Narrowly versus Broadly Defined Autism Spectrum Disorders: Differences in Pre-and Perinatal Risk Factors

Autor/inn/en	Visser, Janne C.; Rommelse, Nanda; Vink, Lianne; Schrieken, Margo; Oosterling, Iris J.; Gaag, Rutger J.; Buitelaar, Jan K.
Titel	Narrowly versus Broadly Defined Autism Spectrum Disorders: Differences in Pre-and Perinatal Risk Factors
Quelle	In: Journal of Autism and Developmental Disorders, 43 (2014) 7, S.1505-1516 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-012-1678-6
Schlagwörter	Autism; Pervasive Developmental Disorders; Children; Symptoms (Individual Disorders); Comparative Analysis; Control Groups; Clinical Diagnosis; Young Children; Birth Order; Prenatal Influences; Mothers; Pregnancy; At Risk Persons; Smoking; Intelligence Quotient; Etiology + Suchen Sie Ihr Suchwort? Autismus; Child; Kind; Kinder; Psychiatrische Symptomatik; Frühe Kindheit; Geburtenfolge; Pränataler Einfluss; Mother; Mutter; Schwangerschaft; Risikogruppe; Rauchen; Intelligenzquotient; Ätiologie
Abstract	This study examined the differential contribution of pre-and perinatal risks in narrowly versus broadly defined autism spectrum disorder (ASD) and across core symptom domains, IQ and co-morbid problems. Children with a DSM-IV diagnosis of autistic disorder (AD) (n = 121) or pervasive developmental disorder not otherwise specified (PDD-NOS) (n = 75) were compared to a typical control sample (n = 311). Diagnoses were based on extensive assessments between 12 and 49 months of age (M = 33.3, SD = 6.4) and re-evaluated at 43-98 months (M = 68.1, SD = 10.7) in 70% of the cases. Compared with controls, cases with ASD were more likely to be firstborn and show a suboptimal condition after birth. Case mothers reported more infections and more stress during pregnancy. Although the ASD subgroups showed mostly overlapping risks, cases with PDD-NOS differed from those with AD by higher exposure to smoking during pregnancy (SDP) and by a negative association of smoking with IQ, regardless of confounders. SDP appears to contribute more to broadly defined (PDD-NOS) than to narrowly defined ASD (AD). Findings suggest differences in etiological contributors between ASD phenotypes. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10