Maternal Vitamin D Levels and the Autism Phenotype among Offspring

Autor/inn/en	Whitehouse, Andrew J. O.; Holt, Barbara J.; Serralha, Michael; Holt, Patrick G.; Hart, Prue H.; Kusel, Merci M. H.
Titel	Maternal Vitamin D Levels and the Autism Phenotype among Offspring
Quelle	In: Journal of Autism and Developmental Disorders, 43 (2013) 7, S.1495-1504 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-012-1676-8
Schlagwörter	Nutrition; Pregnancy; Prenatal Influences; Autism; Mothers; Pervasive Developmental Disorders; Young Adults; Attention; Symptoms (Individual Disorders) + Suchen Sie Ihr Suchwort? Ernährung; Schwangerschaft; Pränataler Einfluss; Autismus; Mother; Mutter; Young adult; Junger Erwachsener; Aufmerksamkeit; Psychiatrische Symptomatik
Abstract	We tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype. Serum 25(OH)-vitamin D concentrations of 929 women were measured at 18 weeks' pregnancy. The mothers of the three children with a clinical diagnosis of autism spectrum disorder had 25(OH)-vitamin D concentrations above the population mean. The offspring of 406 women completed the Autism-Spectrum Quotient in early adulthood. Maternal 25(OH)-vitamin D concentrations were unrelated to offspring scores on the majority of scales. However, offspring of mothers with low 25(OH)-vitamin D concentrations (<49 nmol/L) were at increased risk for "high" scores (=2SD above mean) on the Attention Switching subscale (odds ratio: 5.46, 95% confidence interval: 1.29, 23.05). The involvement of maternal vitamin D during pregnancy in autism requires continued investigation. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10