How and Why Does the 5-HTTLPR Gene Moderate Associations between Maternal Unresponsiveness and Children's Disruptive Problems?

Autor/inn/en	Davies, Patrick T.; Cicchetti, Dante
Titel	How and Why Does the 5-HTTLPR Gene Moderate Associations between Maternal Unresponsiveness and Children's Disruptive Problems?
Quelle	In: Child Development, 85 (2014) 2, S.484-500 (17 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0009-3920
DOI	10.1111/cdev.12148
Schlagwörter	Genetics; Mothers; Parent Child Relationship; Affective Behavior; Behavior Problems; Disadvantaged Youth; African Americans; Young Children; Toddlers; Structural Equation Models; Predictor Variables; Symptoms (Individual Disorders); Hypothesis Testing; At Risk Persons; Responses; Psychological Patterns + Suchen Sie Ihr Suchwort? Humangenetik; Mother; Mutter; Parents-child relationship; Parent-child-relation; Parent-child relationship; Eltern-Kind-Beziehung; Affective disturbance; Active behaviour; Affektive Störung; Benachteiligter Jugendlicher; Afroamerikaner; Frühe Kindheit; Infant; Infants; Toddler; Kleinkind; Prädiktor; Psychiatrische Symptomatik; Hypothesenprüfung; Hypothesentest; Risikogruppe
Abstract	This study tested the 5-HTTLPR gene as a moderator in the relation between maternal unresponsiveness and child externalizing symptoms in a disadvantaged, predominantly Black sample of two hundred and one 2-year-old children and their mothers. Using a multimethod, prospective design, structural equation model analyses indicated that maternal unresponsiveness significantly predicted increases in externalizing symptoms 2 years later only for children possessing the LL genotype. Moderation was expressed in a "for better" or "for worse" form hypothesized in differential susceptibility theory. In examining why the risk posed by maternal unresponsiveness differed across the 5-HTTLPR polymorphism, mediated moderation analyses showed that children's angry reactivity to maternal negativity partly accounted for the greater susceptibility of homozygous L carriers to variations in maternal unresponsiveness. (As Provided).
Anmerkungen	Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10