Gene-Environment Interaction in Externalizing Problems among Adolescents: Evidence from the Pelotas 1993 Birth Cohort Study

Autor/inn/en	Kieling, Christian; Hutz, Mara H.; Genro, Julia P.; Polanczyk, Guilherme V.; Anselmi, Luciana; Camey, Suzi; Hallal, Pedro C.; Barros, Fernando C.; Victora, Cesar G.; Menezes, Ana M. B.; Rohde, Luis Augusto
Titel	Gene-Environment Interaction in Externalizing Problems among Adolescents: Evidence from the Pelotas 1993 Birth Cohort Study
Quelle	In: Journal of Child Psychology and Psychiatry, 54 (2013) 3, S.298-304 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/jcpp.12022
Schlagwörter	Genetics; Biochemistry; Prenatal Influences; Smoking; Mothers; Hyperactivity; Environmental Influences; Mental Disorders; Birth; Behavior Problems; Questionnaires; Child Abuse; Correlation; Adolescents; Mental Health; Foreign Countries; Interviews; Educational Background; Brazil; Strengths and Difficulties Questionnaire + Suchen Sie Ihr Suchwort? Humangenetik; Biochemie; Pränataler Einfluss; Rauchen; Mother; Mutter; Hyperaktivität; Environmental influence; Umwelteinfluss; Mental illness; Geisteskrankheit; Geburt; Fragebogen; Abuse of children; Abuse; Child; Children; Kindesmissbrauch; Missbrauch; Kind; Kinder; Korrelation; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Psychohygiene; Ausland; Interviewing; Interviewtechnik; Vorbildung; Brasilien
Abstract	Background: The study of gene-environment interactions (G by E) is one of the most promising strategies to uncover the origins of mental disorders. Replication of initial findings, however, is essential because there is a strong possibility of publication bias in the literature. In addition, there is a scarcity of research on the topic originated from low- and middle-income countries (LMIC). The aim of this study was to replicate G by E hypotheses for externalizing problems among adolescents in a middle-income country. Methods: As part of the Pelotas 1993 Birth Cohort Study, 5,249 children were enrolled at birth and followed up to the age of 15 years, with an 85.7% retention rate. We sought an interaction between the homozygosity of the 10-repeat allele at the dopamine transporter ("DAT1") gene and prenatal maternal smoking in the development of hyperactivity problems during adolescence assessed by the Strengths and Difficulties Questionnaire. We also tested for an interaction between the uVNTR polymorphism at the monoamine oxidase A ("MAOA") and the experience of childhood maltreatment in the occurrence of conduct problems among adolescent boys. Results: Although there was a clear association between prenatal maternal smoking and hyperactivity scores in adolescence ("p" less than 0.001), no main genetic or interaction effects for the "DAT1" gene were detected. Similarly, childhood maltreatment showed to be associated with conduct problems among boys ("p" less than 0.001), with no observable main genetic or interaction effects for the "MAOA" gene. Conclusions: In the largest mental health G by E study performed in a LMIC to date, we did not replicate previous positive findings from the literature. Despite the presence of main environmental effects, there was no evidence of effect modification by genotype status. Additional replication efforts to measure G by E are needed to better understand the origins of mental health and illness, especially in LMIC. (Contains 1 table and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10