Literaturnachweis - Detailanzeige
| Autor/inn/en | Connolly, John J.; Glessner, Joseph T.; Hakonarson, Hakon |
|---|---|
| Titel | A Genome-Wide Association Study of Autism Incorporating Autism Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule, and Social Responsiveness Scale |
| Quelle | In: Child Development, 84 (2013) 1, S.17-33 (17 Seiten)Infoseite zur Zeitschrift
PDF als Volltext |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0009-3920 |
| DOI | 10.1111/j.1467-8624.2012.01838.x |
| Schlagwörter | Autism; Pervasive Developmental Disorders; Genetics; Genetic Disorders; Biology; Asperger Syndrome; Severity (of Disability); Behavior Problems; Antisocial Behavior; Classification; Communication Problems; Social Development; Nonverbal Communication; Children; Autism Diagnostic Observation Schedule |
| Abstract | Efforts to understand the causes of autism spectrum disorders (ASDs) have been hampered by genetic complexity and heterogeneity among individuals. One strategy for reducing complexity is to target endophenotypes, simpler biologically based measures that may involve fewer genes and constitute a more homogenous sample. A genome-wide association study of 2,165 participants (mean age = 8.95 years) examined associations between genomic loci and individual assessment items from the Autism Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule, and Social Responsiveness Scale. Significant associations with a number of loci were identified, including "KCND2" (overly serious facial expressions), "NOS2A" (loss of motor skills), and "NELL1" (faints, fits, or blackouts). These findings may help prioritize directions for future genomic efforts. (Contains 5 tables and 1 figure.) (As Provided). |
| Anmerkungen | Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/ |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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