Epigenetic Vestiges of Early Developmental Adversity: Childhood Stress Exposure and DNA Methylation in Adolescence

Autor/inn/en	Essex, Marilyn J.; Boyce, W. Thomas; Hertzman, Clyde; Lam, Lucia L.; Armstrong, Jeffrey M.; Neumann, Sarah M. A.; Kobor, Michael S.
Titel	Epigenetic Vestiges of Early Developmental Adversity: Childhood Stress Exposure and DNA Methylation in Adolescence
Quelle	In: Child Development, 84 (2013) 1, S.58-75 (18 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0009-3920
DOI	10.1111/j.1467-8624.2011.01641.x
Schlagwörter	Genetics; Adolescents; Child Development; Longitudinal Studies; Stress Variables; Family Environment; Infants; Mothers; Fathers; Parent Influence; Young Children; Gender Differences; Biology; Environmental Influences; Depression (Psychology); Psychological Patterns; Child Rearing; Parent Role; Family Income; Wisconsin; Parenting Stress Index; Center for Epidemiologic Studies Depression Scale + Suchen Sie Ihr Suchwort? Humangenetik; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Kindesentwicklung; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Familienmilieu; Infant; Toddler; Toddlers; Kleinkind; Mother; Mutter; Frühe Kindheit; Geschlechterkonflikt; Biologie; Environmental influence; Umwelteinfluss; Kindererziehung; Parental role; Elternrolle; Familieneinkommen
Abstract	Fifteen-year-old adolescents (N = 109) in a longitudinal study of child development were recruited to examine differences in DNA methylation in relation to parent reports of adversity during the adolescents' infancy and preschool periods. Microarray technology applied to 28,000 cytosine-guanine dinucleotide sites within DNA derived from buccal epithelial cells showed differential methylation among adolescents whose parents reported high levels of stress during their children's early lives. Maternal stressors in infancy and paternal stressors in the preschool years were most strongly predictive of differential methylation, and the patterning of such epigenetic marks varied by children's gender. To the authors' knowledge, this is the first report of prospective associations between adversities in early childhood and the epigenetic conformation of adolescents' genomic DNA. (Contains 5 figures and 1 table.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10