Language Dysfluencies in Females with the "FMR1" Premutation

Autor/inn/en	Sterling, Audra M.; Mailick, Marsha; Greenberg, Jan; Warren, Steven F.; Brady, Nancy
Titel	Language Dysfluencies in Females with the "FMR1" Premutation
Quelle	In: Brain and Cognition, 82 (2013) 1, S.84-89 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2013.02.009
Schlagwörter	Autism; Early Intervention; Executive Function; Genetic Disorders; Mothers; Age Differences; Language Impairments; Pervasive Developmental Disorders; Correlation; Profiles; Educational Attainment; Neurological Impairments; Mental Retardation + Suchen Sie Ihr Suchwort? Autismus; Mother; Mutter; Age; Difference; Age difference; Altersunterschied; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Korrelation; Charakterisierung; Profilanalyse; Bildungsabschluss; Bildungsgut; Neurodegenerative Erkrankung; Geistige Behinderung
Abstract	Recent evidence suggests that there are age-related neurocognitive implications for fragile X premutation carriers, including deficits in executive function, and that such deficits are more common in male than female premutation carriers. The purpose of the current study is to examine one aspect of executive function, language dysfluencies, in a group of 193 women with the premutation, and to contrast them with a comparison group (mothers of children with autism spectrum disorders). Our results demonstrate a linguistic profile in the female premutation carriers characterized by dysfluencies associated with deficits in organization and planning, with a clear impact of age. The comparison group, matched on both age and education level, did not demonstrate the age effect. Our results suggest dysfluencies could be an early indicator of cognitive aging in some female premutation carriers, and could be used to target early intervention. (Contains 4 tables and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10