Frontal glutamate and reward processing in adolescence and adulthood.

Autor/inn/en	Gleich, Tobias; Lorenz, Robert C.; Pöhland, Lydia; Raufelder, Diana; Deserno, Lorenz; Beck, Anne; Heinz, Andreas; Kühn, Simone; Gallinat, Jürgen
Titel	Frontal glutamate and reward processing in adolescence and adulthood.
Quelle	In: Brain structure & function, 220 (2015) 6, S. 3087-3099 PDF als Volltext Link als defekt meldenVerfügbarkeit
Beigaben	Literaturangaben
Zusatzinformation	Forschungsdaten, Studiendetails und Erhebungsinstrumente
Sprache	englisch
Dokumenttyp	online; gedruckt; Zeitschriftenaufsatz
ISSN	1863-2653; 1863-2661
DOI	10.1007/s00429-014-0844-3
Schlagwörter	Belohnung; Impulsivität; Motivationsforschung; Neuronale Entwicklung; Persönlichkeit; Persönlichkeitsmerkmal; Psychiatrische Symptomatik; Verhalten; Verhaltenstraining; Adoleszenz; Motivation; Gehirn; Hirnforschung; Hirnfunktion; Neurobiologie; Neuronales Netz; Neurotransmitter; Neurowissenschaften; Glutamat; Impuls; Magnetresonanzverfahren; Neurologie; Erwachsenenalter; Erwachsener; Jugendlicher
Abstract	The fronto-limbic network interaction, driven by glutamatergic and dopaminergic neurotransmission, represents a core mechanism of motivated behavior and personality traits. Reward seeking behavior undergoes tremendous changes in adolescence paralleled by neurobiological changes of this network including the prefrontal cortex, striatum and amygdala. Since fronto-limbic dysfunctions also underlie major psychiatric diseases beginning in adolescence, this investigation focuses on network characteristics separating adolescents from adults. To investigate differences in network interactions, the brain reward system activity (slot machine task) together with frontal glutamate concentration (anterior cingulate cortex, ACC) was measured in 28 adolescents and 26 adults employing functional magnetic resonance imaging and magnetic resonance spectroscopy, respectively. An inverse coupling of glutamate concentrations in the ACC and activation of the ventral striatum was observed in adolescents. Further, amygdala response in adolescents was negatively correlated with the personality trait impulsivity. For adults, no significant associations of network components or correlations with impulsivity were found. The inverse association between frontal glutamate concentration and striatal activation in adolescents is in line with the triadic model of motivated behavior stressing the important role of frontal top-down inhibition on limbic structures. Our data identified glutamate as the mediating neurotransmitter of this inhibitory process and demonstrates the relevance of glutamate on the reward system and related behavioral traits like impulsivity. This fronto-limbic coupling may represent a vulnerability factor for psychiatric disorders starting in adolescence but not in adulthood. (Orig.).
Erfasst von	DIPF \| Leibniz-Institut für Bildungsforschung und Bildungsinformation, Frankfurt am Main
Update	2022/2