Dopaminergic gene polymorphisms affect long-term forgetting in old age. Further support for the magnification hypothesis.

Autor/inn/en	Papenberg, Goran; Bäckman, Lars; Nagel, Irene E.; Nietfeld, Wilfried; Schröder, Julia; Bertram, Lars; Heekeren, Hauke R.; Lindenberger, Ulman; Li, Shu-Chen
Titel	Dopaminergic gene polymorphisms affect long-term forgetting in old age. Further support for the magnification hypothesis.
Quelle	In: Journal of cognitive neuroscience, 25 (2013) 4, S. 571-579 PDF als Volltext Link als defekt meldenVerfügbarkeit
Beigaben	Literaturangaben
Sprache	englisch
Dokumenttyp	online; Zeitschriftenaufsatz
ISSN	1530-8898
DOI	10.1162/jocn_a_00359
Schlagwörter	Bildungsforschung; Empirische Untersuchung; Gedächtnis; Vergessen; Genetik; Junger Erwachsener; Deutschland
Abstract	Emerging evidence from animal studies suggests that suboptimal dopamine (DA) modulation may be associated with increased forgetting of episodic information. Extending these observations, we investigated the influence of DA-relevant genes on forgetting in samples of younger (n = 433, 20-31 years) and older (n = 690, 59-71 years) adults. The effects of single nucleotide polymorphisms of the DA D2 (DRD2) and D3 (DRD3) receptor genes as well as the DA transporter gene (DAT1; SLC6A3) were examined. Over the course of one week, older adults carrying two or three genotypes associated with higher DA signaling (i.e., higher availability of DA and DA receptors) forgot less pictorial information than older individuals carrying only one or no beneficial genotype. No such genetic effects were found in younger adults. The results are consistent with the view that genetic effects on cognition are magnified in old age. To the best of our knowledge, this is the first report to relate genotypes associated with suboptimal DA modulation to more long-term forgetting in humans. Independent replication studies in other populations are needed to confirm the observed association. (DIPF/Orig.).
Erfasst von	DIPF \| Leibniz-Institut für Bildungsforschung und Bildungsinformation, Frankfurt am Main
Update	2015/4