Co-Localisation of Abnormal Brain Structure and Function in Specific Language Impairment

Autor/inn/en	Badcock, Nicholas A.; Bishop, Dorothy V. M.; Hardiman, Mervyn J.; Barry, Johanna G.; Watkins, Kate E.
Titel	Co-Localisation of Abnormal Brain Structure and Function in Specific Language Impairment
Quelle	In: Brain and Language, 120 (2012) 3, S.310-320 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0093-934X
DOI	10.1016/j.bandl.2011.10.006
Schlagwörter	Siblings; Language Impairments; Expressive Language; Morphology (Languages); Brain Hemisphere Functions; Naming; Control Groups; Developmental Disabilities; Suprasegmentals; Correlation; Diagnostic Tests; Auditory Stimuli; Task Analysis; Language Processing; Intonation; Neurological Impairments + Suchen Sie Ihr Suchwort? Sibling; Geschwister; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Morphology; Morphologie; Entwicklungsstörung; Korrelation; Diagnostic test; Diagnostischer Test; Auditive Stimulation; Aufgabenanalyse; Sprachverarbeitung; Neurodegenerative Erkrankung
Abstract	We assessed the relationship between brain structure and function in 10 individuals with specific language impairment (SLI), compared to six unaffected siblings, and 16 unrelated control participants with typical language. Voxel-based morphometry indicated that grey matter in the SLI group, relative to controls, was increased in the left inferior frontal cortex and decreased in the right caudate nucleus and superior temporal cortex bilaterally. The unaffected siblings also showed reduced grey matter in the caudate nucleus relative to controls. In an auditory covert naming task, the SLI group showed reduced activation in the left inferior frontal cortex, right putamen, and in the superior temporal cortex bilaterally. Despite spatially coincident structural and functional abnormalities in frontal and temporal areas, the relationships between structure and function in these regions were different. These findings suggest multiple structural and functional abnormalities in SLI that are differently associated with receptive and expressive language processing. (Contains 3 tables, 3 supplementary tables and 6 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10