Insights into Spared Memory Capacity in Amnestic MCI and Alzheimer's Disease via Minimal Interference

Autor/inn/en	Dewar, Michaela; Pesallaccia, Martina; Cowan, Nelson; Provinciali, Leandro; Della Sala, Sergio
Titel	Insights into Spared Memory Capacity in Amnestic MCI and Alzheimer's Disease via Minimal Interference
Quelle	In: Brain and Cognition, 78 (2012) 3, S.189-199 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2011.12.005
Schlagwörter	Structural Elements (Construction); Models; Alzheimers Disease; Word Lists; Visual Stimuli; Diseases; Memory; Memorization; Tests; Recall (Psychology); Retention (Psychology); Time Factors (Learning); Standardized Tests; Patients; Control Groups; Older Adults + Suchen Sie Ihr Suchwort? Analogiemodell; Wortliste; Disease; Krankheit; Gedächtnis; Gedächtnistraining; Examination; Prüfung; Examen; Abberufung; Merkfähigkeit; Standadised tests; Standardisierter Test; Patient; Älterer Erwachsener
Abstract	Impairment on standard tests of delayed recall is often already maximal in the aMCI stage of Alzheimer's Disease. Neuropathological work shows that the neural substrates of memory function continue to deteriorate throughout the progression of the disease, hinting that further changes in memory performance could be tracked by a more sensitive test of delayed recall. Recent work shows that retention in aMCI patients can be raised well above floor when the delay period is devoid of further material--"Minimal Interference". This memory enhancement is thought to be the result of improved memory consolidation. Here we used the minimal interference/interference paradigm (word list retention following 10 min of quiet resting vs. picture naming) in a group of 17 AD patients, 25 aMCI patients and 25 controls. We found (1) that retention can be improved significantly by minimal interference in patients with aMCI and patients with mild to moderate AD; (2) that the minimal interference paradigm is sensitive to decline in memory function with disease severity, even when performance on standard tests has reached floor; and (3) that this paradigm can differentiate well (80% sensitivity and 100% specificity) between aMCI patients who progress and do not progress to AD within 2 years. Our findings support the notion that the early memory dysfunction in AD is associated with an increased susceptibility to memory interference and are suggestive of a gradual decline in consolidation capacity with disease progression. (Contains 5 figures and 2 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10