Perirhinal Cortex Lesions Produce Retrograde Amnesia for Spatial Information in Rats: Consolidation or Retrieval?

Autor/in	Ramos, Juan M. J.
Titel	Perirhinal Cortex Lesions Produce Retrograde Amnesia for Spatial Information in Rats: Consolidation or Retrieval?
Quelle	In: Learning & Memory, 15 (2008) 8, S.587-596 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1036308
Schlagwörter	Surgery; Spatial Ability; Animals; Experiments; Brain; Neuropsychology; Drug Therapy; Recall (Psychology); Retention (Psychology); Learning Processes + Suchen Sie Ihr Suchwort? Chirurgie; Räumliches Vorstellungsvermögen; Animal; Tier; Tiere; Erprobung; Gehirn; Neuropsychologie; Abberufung; Merkfähigkeit; Learning process; Lernprozess
Abstract	Several lines of evidence in humans and experimental animals suggest that the hippocampus is critical for the formation and retrieval of spatial memory. However, although the hippocampus is reciprocally connected to adjacent cortices within the medial temporal lobe and they, in turn, are connected to the neocortex, little is known regarding the function of these cortices in memory. Here, using a reference spatial memory task in the radial maze, we show that neurotoxic perirhinal cortex lesions produce a profound retrograde amnesia when learning-surgery intervals of 1 or 50 d are used (Experiment 1). With the aim of dissociating between consolidation and retrieval processes, we injected lidocaine either daily after training (Experiment 2) or before a retention test once the learning had been completed (Experiment 3). Results show that reversible perirhinal inactivation impairs retrieval but not consolidation. However, the same procedure followed in Experiment 2 disrupted consolidation when the lidocaine was injected into the dorsal hippocampus. The results of Experiment 4 rule out the possibility that the deficit in retrieval is due to a state-dependent effect. These findings demonstrate the differential contribution of various regions of the medial temporal lobe to memory, suggesting that the perirhinal cortex plays a key role in the retrieval of spatial information for a long period of time. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10